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Recombinant Mouse Alpha Crystallin B

CAT: 0014-11073MP-1Size: 1000 µgDry Ice: NoHazardous: No
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CAT#:0014-11073MP-1Size:1000 µg
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Description
Recombinant Mouse Alpha Crystallin B
CAS Number
9000-83-3
Product Name Alternative
CRYAB Mouse
Gene Name
Cryab
UniProt
P23927
Cellular Locus
Cytoplasm, cytosol , Nucleus , Secreted , Lysosome , Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Localizes at the Z-bands and the intercalated disk in cardiomyocytes. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Reactivity
Mouse
Target Antigen
Alpha Crystallin B
Target
Alpha Crystallin B
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (PubMed:31786107). {PubMed:31786107}.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below -20°C for longer periods of time. For long term storage, addition of a carrier protein (0.1% HSA or BSA) is recommended.
Specificity
Alpha Crystallin B
Formulation
Sterile-filtered colorless solution contains 20mM Tris buffer, pH 8.0 and 10% glycerol.
Buffer pH
pH 8.0
Target Background
Alpha crystallins are composed of two gene products: alpha-A (acidic) and alpha-B (basic). Alpha crystallins are induced by heat shock and are members of the small heat shock protein family. They act as molecular chaperones. In addition, alpha crystallins have autokinase activity and play a role in intracellular architecture. Alpha crystallin B is expressed in many tissues and is associated with many neurological diseases.

UniProtKB · P23927

Alpha-crystallin B chain

CRYAB_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P23927
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Cryab
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q64325
Protein keywords

PTM

AcetylationMethylationPhosphoprotein

Molecular function

ChaperoneEye lens protein

Cellular component

CytoplasmLysosomeNucleusSecreted

Technical term

Direct protein sequencingReference proteome

Ligand

Metal-bindingZinc

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