PKC-IN-1

PKC-IN-1

• CAS Number: 1046787-18-1
• UNSPSC Description: PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.
• Target Antigen: PKC
• Type: Reference compound
• Related Pathways: Epigenetics;TGF-beta/Smad
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/PKC-IN-1.html
• Solubility: DMSO : ≥ 25 mg/mL
• Smiles: O=C(N1[C@@H](C)CN(CC2CCOCC2)[C@H](C)C1)N(C3)C(C)(C)C4=C3C(NC5=NC(C)=NC=C5F)=NN4
• Molecular Weight: 500.61
• References & Citations: [1]Michael Niesman, et al. Treatment of autoimmune disease. WO2015179847A1.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported