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Recombinant Human SERPINH1

CAT: 0014-11125P-1Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0014-11125P-1Size:10 µg
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Description
Recombinant Human SERPINH1
CAS Number
9000-83-3
Product Name Alternative
Hsp47
Gene Name
SERPINH1
UniProt
P50454
Cellular Locus
Endoplasmic reticulum lumen.
Reactivity
Human
Target Antigen
Serpin H1
Target
SERPINH1
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.
Specificity
SERPINH1
Formulation
Sterile-filtered colorless solution (1mg/ml) in 20mM Tris-HCl, pH 8.0, and 10% glycerol.
Buffer pH
pH 8.0
Target Background
SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors whose expression is induced by heat shock. As a molecular chaperone, it localizes to the endoplasmic reticulum lumen and binds collagen, thus participating in the maturation of collagen molecules, facilitating the folding and assembly of procollagen molecules, retaining unfolded molecules within the ER, and assisting in the transport of correctly folded molecules from the ER to the Golgi apparatus. Autoantibodies to SERPINH1 have been found in cases of rheumatoid arthritis.

UniProtKB · P50454

Serpin H1

SERPH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P50454
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SERPINH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B3KVJ3, P29043, Q5XPB4, Q6NSJ6, Q8IY96, Q9NP88
Protein keywords

PTM

AcetylationGlycoproteinPhosphoprotein

Molecular function

Chaperone

Cellular component

Endoplasmic reticulum

Disease

Osteogenesis imperfecta

Technical term

Proteomics identificationReference proteome

Domain

Signal

Biological process

Stress response

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