Aprindine (hydrochloride)
CAT:
804-HY-A0236A-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Aprindine (hydrochloride)
- CAS Number: 33237-74-0
- UNSPSC Description: Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.
- Target Antigen: Potassium Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Applications: Neuroscience-Neuromodulation
- Field of Research: Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/aprindine-hydrochloride.html
- Purity: 98.96
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CCN(CC)CCCN(C1CC2=C(C=CC=C2)C1)C3=CC=CC=C3.[H]Cl
- Molecular Weight: 358.95
- References & Citations: [1]Y Ohmoto-Sekine, et al. Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells. Br J Pharmacol. 1999 Feb;126(3):751-61.|[2]M L De Bruin, et al . Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. Eur Heart J. 2005 Mar;26(6):590-7.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported