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Aprindine

CAT: 0804-HY-A0236-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0236-01Size:5 mg
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Description
Aprindine is an Ib-class anti-arrhythmic agent. Aprindine mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias[1][2][3][4][5].
CAS Number
37640-71-4
UNSPSC
12352005
Target
Calcium Channel; Calmodulin; Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/aprindine.html
Purity
98.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN(CC)CCCN(C1CC2=C(C=CC=C2)C1)C3=CC=CC=C3
Molecular Formula
C22H30N2
Molecular Weight
322.49
References & Citations
[1]Stryckmans P A, Ronge‐Collard E, Delforge A, et al. Effect of 2 Anti‐Arrhythmic Drugs Aprindine and Moxaprindine on the Replication Capacity of Murine and Human Haemopoietic Cells[J]. Scandinavian journal of haematology, 1982, 29 (4) : 331-337.|[2]Watanabe Y, et al. Inhibitory effect of aprindine on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes. Br J Pharmacol. 2002 Jun;136 (3) :361-6.|[3]Y Ohmoto-Sekine, et al. Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells. Br J Pharmacol. 1999 Feb;126 (3) :751-61.|[4]Levine SN, Hollier B. Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J Cardiovasc Pharmacol. 1983 Jan-Feb;5 (1) :151-6.|[5]Brooks RR, et al. Broad sensitivity of rodent arrhythmia models to class I, II, III, and IV antiarrhythmic agents. Proc Soc Exp Biol Med. 1989 Jun;191 (2) :201-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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