JNJ-42226314
CAT:
804-HY-133130-05
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
JNJ-42226314
- CAS Number: 1252765-13-1
- UNSPSC Description: JNJ-42226314 is a competitive, highly selective and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. JNJ-42226314 demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) as well as efficacy in models of neuropathic and inflammatory pain[1].
- Target Antigen: MAGL
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/jnj-42226314.html
- Smiles: O=C(N1CCN(C2CN(C(C3=CC4=C(N(C5=CC=C(F)C=C5)C=C4)C=C3)=O)C2)CC1)C6=NC=CS6
- Molecular Weight: 489.56
- References & Citations: [1]Wyatt RM, et al.Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor.J Pharmacol Exp Ther. 2019 Dec 9.
- Shipping Conditions: Room Temperature