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VU0486321

CAT: 0804-HY-118179-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118179-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs) . VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.
CAS Number
1816301-67-3
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0486321.html
Purity
99.30
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=C2C(C(N(C2=O)C3=CC=C(C=C3Cl)NC(C4=C(C=CO4)C)=O)=O)=CC=C1
Molecular Formula
C20H12ClFN2O4
Molecular Weight
398.77
References & Citations
[1]Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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