(+) -JQ-1

CAT: 0804-HY-13030-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-13030-01Size:2 mg

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Description

(+) -JQ-1 (JQ1), a chemical probe, is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4 (1/2) ) [1]. (+) -JQ-1 also activates autophagy[2].

CAS Number

1268524-70-4

Product Name Alternative

JQ1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Epigenetic Reader Domain; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Autophagy; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/__addition__-JQ-1.html

Purity

99.90

Solubility

DMSO : ≥ 45 mg/mL

Smiles

O=C(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)OC(C)(C)C

Molecular Formula

C23H25ClN4O2S

Molecular Weight

456.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468 (7327) :1067-73.|[2]Sakamaki JI, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and LysosomalFunction. Mol Cell. 2017 May 18;66 (4) :517-532.e9.|[3]Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150 (4) :673-84.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

BRD4

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abx181384-01	(+)-Jq-1
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281048-01	(+) -JQ-1
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