(+) -JQ-1

• Description:

  (+) -JQ-1 (JQ1), a chemical probe, is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4 (1/2) ) [1]. (+) -JQ-1 also activates autophagy[2].

• Product Name Alternative:

  JQ1

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; Epigenetic Reader Domain; Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/__addition__-JQ-1.html

• Purity:

  99.90

• Solubility:

  DMSO : ≥ 45 mg/mL

• Smiles:

  O=C(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)OC(C)(C)C

• Molecular Formula:

  C23H25ClN4O2S

• Molecular Weight:

  456.99

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468 (7327) :1067-73.|[2]Sakamaki JI, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and LysosomalFunction. Mol Cell. 2017 May 18;66 (4) :517-532.e9.|[3]Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150 (4) :673-84.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  BRD4

• CAS Number:

  [1268524-70-4]