Magainin 1

• Description:

  Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria[1][2][3].

• Product Name Alternative:

  Magainin I

• UNSPSC:

  12352209

• Target:

  Antibiotic; Bacterial; Fungal

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Magainin_1.html

• Purity:

  99.92

• Solubility:

  H2O : 50 mg/mL

• Smiles:

  [C@H] (CC1=CC=CC=C1) (C (N[C@H] (C (N[C@@H] (CC2=CN=CN2) C (N[C@H] (C (N[C@H] (C (NCC (N[C@H] (C (N[C@@H] (CC3=CC=CC=C3) C (NCC (N[C@H] (C (N[C@H] (C (N[C@@H] (CC4=CC=CC=C4) C (N[C@H] (C (NCC (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (O) =O) CO) =O) CCCCN) =O) CCSC) =O) [C@H] (CC) C) =O) CCC (O) =O) =O) =O) C (C) C) =O) =O) C) =O) CCCCN) =O) =O) =O) CCCCN) =O) =O) C) =O) CO) =O) =O) CC (C) C) =O) NC ([C@@H] (NC (CNC ([C@@H] (NC (CN) =O) [C@H] (CC) C) =O) =O) CCCCN) =O

• Molecular Formula:

  C112H177N29O28S

• Molecular Weight:

  2409.85

• References & Citations:

  [1]Duclohier H, et al. Antimicrobial peptide magainin I from Xenopus skin forms anion-permeable channels in planar lipid bilayers. Biophys J. 1989 Nov;56 (5) :1017-21.|[2]Matsuzaki K, et al. Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles. Biochim Biophys Acta. 1989 May 19;981 (1) :130-4.|[3]Zasloff M, et al. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84 (15) :5449-53.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  108433-99-4