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Apomine

CAT: 0804-HY-19671-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19671-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apomine (SR-45023A) is an orally active antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) . Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer[1][2].
CAS Number
126411-13-0
Product Name Alternative
SR-45023A; SR 9223i; SK&F-99085
UNSPSC
12352005
Target
Apoptosis; HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apomine.html
Purity
99.67
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CC(P(OC(C)C)(OC(C)C)=O)P(OC(C)C)(OC(C)C)=O)=C1
Molecular Formula
C28H52O7P2
Molecular Weight
562.66
References & Citations
[1]Kuehl PJ, et al. Preformulation, formulation, and in vivo efficacy of topically applied apomine. Int J Pharm. 2009;382 (1-2) :104-110.|[2]Edwards CM, et al. Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Int J Cancer. 2007 Apr 15;120 (8) :1657-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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