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Tropicamide-d3

CAT: 0804-HY-B0321S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0321S-01Size:1 mg
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Description
Tropicamide-d3 is the deuterium labeled Tropicamide[1]. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops[2][3].
CAS Number
2673270-13-6
Product Name Alternative
Ro 1-7683-d3
UNSPSC
12352005
Target
MAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.10
Solubility
DMF : ≥ 30mg/mL|DMSO : ≥ 30mg/mL|Ethanol : ≥ 30mg/mL
Smiles
[2H]C([2H])([2H])CN(CC1=CC=NC=C1)C(C(C2=CC=CC=C2)CO)=O
Molecular Formula
C17H17D3N2O2
Molecular Weight
287.37
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38 (6) : p. 805-15.|[3]Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110 (4) : p. 1413-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Launched

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