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Tropicamide

CAT: 0804-HY-B0321-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0321-01Size:100 mg
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Description
Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. When used as an eye drop, Tropicamide causes short-term mydriasis (pupil dilation) and cycloplegia. Tropicamide can be used in the research of neurological diseases, such as epilepsy[1][2][3][4].
CAS Number
1508-75-4
Product Name Alternative
Ro 1-7683
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tropicamide.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO
Molecular Formula
C17H20N2O2
Molecular Weight
284.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38 (6) : p. 805-15.|[2]Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110 (4) : p. 1413-20.|[3]Veeraragavan S, et al. The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide. Behav Neurosci. 2011 Oct;125 (5) :783-90.|[4]Betz AJ, et al. The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl) . 2007 Oct;194 (3) :347-59.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Launched
Isoform
MAChR4

Alternative Products

CatalogName
T1281-01Tropicamide

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