2,4′-Dihydroxybenzophenone (Standard)

2,4′-Dihydroxybenzophenone (Standard)

• CAS Number: 131-56-6
• UNSPSC Description: 2,4′-Dihydroxybenzophenone (Standard) is the analytical standard of 2,4′-Dihydroxybenzophenone. This product is intended for research and analytical applications. 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber[1][2].
• Target Antigen: IRAK; MyD88; NF-κB; Reactive Oxygen Species; Toll-like Receptor (TLR)
• Type: Reference Standards
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/2-4-dihydroxybenzophenone-standard.html
• Smiles: OC1=CC(O)=C(C(C2=CC=CC=C2)=O)C=C1
• Molecular Weight: 214.22
• References & Citations: [1]Kavinda MHD, et al. 2,4'-Dihydroxybenzophenone: A Promising Anti-Inflammatory Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor 2-Mediated Mitochondrial Reactive Oxygen Species Production during Lipopolysaccharide-Induced Systemic Inflammation. ACS Pharmacol Transl Sci. 2024 Apr 27;7(5):1320-1334. |[2]Fang Z, et al. Effect of Substituent Groups on the Strength of Intramolecular Hydrogen Bonds in 2,4-Dihydroxybenzophenone UV Absorbers. Molecules. 2023 Jun 27;28(13):5017.
• Shipping Conditions: Room temperature