2,4′-Dihydroxybenzophenone

• Description :

  2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber[1][2].

• Product Name Alternative :

  Ultraviolet absorber UV-0

• UNSPSC :

  12352005

• Hazard Statement :

  H319, H361, H411

• Target :

  IRAK; MyD88; NF-κB; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/2-4-dihydroxybenzophenone.html

• Purity :

  98.00

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  OC1=CC(O)=C(C(C2=CC=CC=C2)=O)C=C1

• Molecular Formula :

  C13H10O3

• Molecular Weight :

  214.22

• Precautions :

  H319, H361, H411

• References & Citations :

  [1]Kavinda MHD, et al. 2,4'-Dihydroxybenzophenone: A Promising Anti-Inflammatory Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor 2-Mediated Mitochondrial Reactive Oxygen Species Production during Lipopolysaccharide-Induced Systemic Inflammation. ACS Pharmacol Transl Sci. 2024 Apr 27;7 (5) :1320-1334. |[2]Fang Z, et al. Effect of Substituent Groups on the Strength of Intramolecular Hydrogen Bonds in 2,4-Dihydroxybenzophenone UV Absorbers. Molecules. 2023 Jun 27;28 (13) :5017.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [131-56-6]