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2,4′-Dihydroxybenzophenone

CAT: 0804-HY-W014223-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W014223-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber[1][2].
CAS Number
131-56-6
Product Name Alternative
Ultraviolet absorber UV-0
UNSPSC
12352005
Hazard Statement
H319, H361, H411
Target
IRAK; MyD88; NF-κB; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-4-dihydroxybenzophenone.html
Purity
98.00
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OC1=CC(O)=C(C(C2=CC=CC=C2)=O)C=C1
Molecular Formula
C13H10O3
Molecular Weight
214.22
Precautions
H319, H361, H411
References & Citations
[1]Kavinda MHD, et al. 2,4'-Dihydroxybenzophenone: A Promising Anti-Inflammatory Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor 2-Mediated Mitochondrial Reactive Oxygen Species Production during Lipopolysaccharide-Induced Systemic Inflammation. ACS Pharmacol Transl Sci. 2024 Apr 27;7 (5) :1320-1334. |[2]Fang Z, et al. Effect of Substituent Groups on the Strength of Intramolecular Hydrogen Bonds in 2,4-Dihydroxybenzophenone UV Absorbers. Molecules. 2023 Jun 27;28 (13) :5017.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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