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Helioxanthin 8-1

CAT: 0804-HY-16680Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16680Size:1 mg
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Description
Helioxanthin 8-1 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 uM. IC50 value: >5/10/1.4/15 uM (HBV/HCV/HSV-1/HIV) [1] Target: Antiviral agent The cyclic hydrazide 28 (Helioxanthin 8-1) showed the most potent antiHBV activity among those helioxanthin analogues tested. In addition, compound 28 exhibited moderately potent activity against HIV. It would therefore be promising to study helioxanthin analogues that contain a six-membered ring instead of the five-membered ring found in the lactam [1]. 8-1 exhibited effective inhibition on DHBV replication. The combination of 8-1 with 3TC resulted in additional anti-DHBV activity. Viral induced cells displayed higher susceptibility to 8-1 treatment than non-induced cells. HBV X protein might not be an essential factor in the initiation of the biological activity of 8-1, as demonstrated by its absence in DHBV [2].
CAS Number
840529-13-7
Product Name Alternative
Helioxanthin analogue 8-1
UNSPSC
12352005
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Helioxanthin-8-1.html
Purity
98.58
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1NNC(C2=C(C3=CC=C(OCO4)C4=C3)C5=C6C(OCO6)=CC=C5C=C21)=O
Molecular Formula
C20H12N2O6
Molecular Weight
376.32
References & Citations
[1]Yeo H, et al. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48 (2) :534-46.|[2]Ying C, et al. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21 (2) :97-103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

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TBZ0405Helioxanthin
B4701-5Helioxanthin 8-1
MBS130249-01Helioxanthin-8-1
MBS130251-01Helioxanthin, ACH 126447
A20880-50Helioxanthin 8-1 50mg
A20880-10Helioxanthin 8-1 10mg
A20880-1Helioxanthin 8-1 1mg
A20880-5Helioxanthin 8-1 5mg
MBS130250-01Helioxanthin 5-4-2
A20880-100Helioxanthin 8-1 100mg

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