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SR1555

CAT: 0804-HY-120785-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120785-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases[1].
CAS Number
[1386439-51-5]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sr1555.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1CCN(CC2=CC=C(C3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3)C=C2)CC1)=O
Molecular Formula
C22H22F6N2O2
Molecular Weight
460.41
References & Citations
[1]Solt LA, Kumar N, He Y, Kamenecka TM, Griffin PR, Burris TP. Identification of a selective RORγ ligand that suppresses T (H) 17 cells and stimulates T regulatory cells. ACS Chem Biol. 2012 Sep 21;7 (9) :1515-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ

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