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BAZ2-ICR

CAT: 0804-HY-19336-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19336-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe[1].
CAS Number
1665195-94-7
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/baz2-icr.html
Purity
99.95
Solubility
DMF : 20 mg/mL (ultrasonic; warming) |DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
N#CC1=CC=C(C2=C(C3=CN(C)N=C3)N=CN2CCC4=CN(C)N=C4)C=C1
Molecular Formula
C20H19N7
Molecular Weight
357.41
References & Citations
[1]Drouin L, et al. Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58 (5) :2553-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
B4915-10BAZ2-ICR
bs-60226C-01BAZ2-ICR --- BAZ2 Bromodomain Inhibitor
A15947-25BAZ2-ICR 25mg
A15947-10BAZ2-ICR 10mg
A15947-500BAZ2-ICR 500mg
A15947-200BAZ2-ICR 200mg
A15947-50BAZ2-ICR 50mg
A15947-1000BAZ2-ICR 1g
A15947-5BAZ2-ICR 5mg
A15947-2000BAZ2-ICR 2g

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