Products for Research Use Only
RegisterLogin

CM398

CAT: 0804-HY-145628-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-145628-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold) . CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM) . CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice[1].
CAS Number
1121931-70-1
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cm398.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C)C2=C(N1CCCCN3CC4=CC(OC)=C(C=C4CC3)OC)C=CC=C2
Molecular Formula
C23H29N3O3
Molecular Weight
395.49
References & Citations
[1]Intagliata S, et al. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1- (4- (6,7-Dimethoxy-3,4-dihydroisoquinolin-2 (1H) -yl) butyl) -3-methyl-1H-benzo[d]imidazol-2 (3H) -one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. AAPS J. 2020;22 (5) :94. Published 2020 Jul 20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor

Alternative Products

CatalogName
C8414-5CM398

Popular Products