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CM398

CAT: 0931-T61846-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T61846-01Size:1 mL - 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1121931-70-1
Target
Others, Sigma receptor
Related Pathways
GPCR/G Protein, Others
Bioactivity
CM398 is an orally active chemical compound that acts as a highly selective ligand for the sigma-2 receptor (K i =0.43 nM), demonstrating a significant ratio of selectivity between sigma-1 and sigma-2 receptors (1000-fold) . Moreover, CM398 exhibits notable affinity towards dopamine (K i =32.90 nM) and serotonin transporters (K i =244.2 nM) . In addition, CM398 has shown promising efficacy as an anti-inflammatory analgesic in a mouse model of inflammatory pain induced by formalin [1].
Smiles
COc1cc2CCN(CCCCn3c4ccccc4n(C)c3=O)Cc2cc1OC
Molecular Formula
C23H29N3O3
Molecular Weight
395.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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T69366-01CM39

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CatalogName
C8414-5CM398

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