EIF2α activator 1
CAT:
804-HY-147831-03
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EIF2α activator 1
- CAS Number: 2851820-52-3
- UNSPSC Description: EIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 1 increases the expression level of eIF2α downstream proteins, ATF and CHOP. EIF2α activator 1 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.00 and 19.3 μM, respectively[1].
- Target Antigen: Eukaryotic Initiation Factor (eIF)
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/eif2α-activator-1.html
- Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: N#CC1=CC(C(F)(F)F)=CC(NC2=C(C(C2=O)=O)N[C@@H]3CC[C@@H](OC4=CC=C(C=C4)C(F)(F)F)CC3)=C1
- Molecular Weight: 523.43
- References & Citations: [1]Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported