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Aviculin

CAT: 0804-HY-N10481Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-N10481Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
156765-33-2
UNSPSC Description
Aviculin, a lignan glycoside, is a potent anticancer agent. Aviculin reduces metabolic activity on MCF-7 cells below 50%, with an IC50 of 75.47 μM. Aviculin induces breast cancer cell apoptosis through the intrinsic apoptosis pathway. Aviculin increases expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP). Aviculin shows an increase in the Bax/Bcl-2 ratio[1].
Target Antigen
Apoptosis; Bcl-2 Family; Caspase; PARP
Type
Natural Products
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aviculin.html
Solubility
10 mM in DMSO
Smiles
O[C@H]([C@@H]([C@H]([C@@H](O1)C)O)O)[C@@H]1OC[C@@H]2[C@@H](C3=CC(OC)=C(C=C3)O)C4=CC(O)=C(OC)C=C4C[C@H]2CO
Molecular Weight
506.54
References & Citations
[1]Lee D, et al. Aviculin Isolated from Lespedeza cuneata Induce Apoptosis in Breast Cancer Cells through Mitochondria-Mediated Caspase Activation Pathway. Molecules. 2020 Apr 8;25(7):1708.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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