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Aviculin

CAT: 0931-T73403-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T73403-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
156765-33-2
Target
Others, Caspase, PARP, Apoptosis, Bcl-2 Family
Related Pathways
Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic, Others, Proteases/Proteasome
Bioactivity
Aviculin, a lignan glycoside, exhibits significant anticancer properties, particularly in inhibiting the metabolic activity of MCF-7 cells to below 50%, with an IC 50 value of 75.47 μM. It promotes apoptosis in breast cancer cells via the intrinsic apoptosis pathway, enhancing the expression of initiator caspase-9, executioner caspase-7, and poly (ADP-ribose) polymerase (PARP) . Furthermore, Aviculin leads to an increased Bax/Bcl-2 ratio, underlying its potential as an effective anticancer agent.
Smiles
C(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)[C@@H]2[C@H](C=3C(C[C@H]2CO)=CC(OC)=C(O)C3)C4=CC(OC)=C(O)C=C4
Molecular Formula
C26H34O10
Molecular Weight
506.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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