Solifenacin

Solifenacin

• CAS Number: 242478-37-1
• UNSPSC Description: Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
• Target Antigen: mAChR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Solifenacin.html
• Purity: 99.83
• Solubility: DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
• Smiles: O=C(O[C@@]1([H])C[N@]2CC[C@@H]1CC2)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5
• Molecular Weight: 362.46
• References & Citations: [1]Ikeda K, et al. M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol. 2002 Aug;366(2):97-103.|[2]Suzuki M, et al. Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarctedrats. Eur J Pharmacol. 2005 Apr 4;512(1):61-6.Int J Nanomedicine. 2024 Aug 15:19:8353-8371.|J Chem Neuroanat. 2023 Dec 18:102375.|Neurourol Urodyn. 2017 Apr;36(4):1026-1033.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched