Solifenacin

• Description :

  Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

• Product Name Alternative :

  YM905 (free base)

• UNSPSC :

  12352005

• Hazard Statement :

  H361

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Solifenacin.html

• Purity :

  99.77

• Solubility :

  DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C(O[C@@]1([H])C[N@]2CC[C@@H]1CC2)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5

• Molecular Formula :

  C23H26N2O2

• Molecular Weight :

  362.46

• Precautions :

  H361

• References & Citations :

  [1]Ikeda K, et al. M (3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol. 2002 Aug;366 (2) :97-103.|[2]Suzuki M, et al. Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarctedrats. Eur J Pharmacol. 2005 Apr 4;512 (1) :61-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  MAChR1; mAChR2; mAChR3

• Citation 01 :

  Int J Nanomedicine. 2024 Aug 15:19:8353-8371.|J Chem Neuroanat. 2024 Mar:136:102375.|Neurourol Urodyn. 2017 Apr;36 (4) :1026-1033.

• CAS Number :

  [242478-37-1]