Solifenacin

CAT: 0804-HY-A0034-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-A0034-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

CAS Number

242478-37-1

Product Name Alternative

YM905 (free base)

UNSPSC

12352005

Hazard Statement

H361

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Solifenacin.html

Purity

99.77

Solubility

DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=C(O[C@@]1([H])C[N@]2CC[C@@H]1CC2)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5

Molecular Formula

C23H26N2O2

Molecular Weight

362.46

Precautions

H361

References & Citations

[1]Ikeda K, et al. M (3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch Pharmacol. 2002 Aug;366 (2) :97-103.|[2]Suzuki M, et al. Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarctedrats. Eur J Pharmacol. 2005 Apr 4;512 (1) :61-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

MAChR1; mAChR2; mAChR3

Citation 01

Int J Nanomedicine. 2024 Aug 15:19:8353-8371.|J Chem Neuroanat. 2024 Mar:136:102375.|Neurourol Urodyn. 2017 Apr;36 (4) :1026-1033.

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Solifenacin

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