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POSH-IN-2

CAT: 0804-HY-164566-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164566-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a DRP1 inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors[1].
CAS Number
348145-43-7
UNSPSC
12352005
Target
Dynamin; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Cytoskeleton; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/posh-in-2.html
Purity
99.65
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; adjust pH to 2 with TFA; heat to 60°C)
Smiles
O=C(C1=CC=C(C(/C=C/C2=CC=CN=C2)=O)C=C1)/C=C/C3=CC=CN=C3
Molecular Formula
C22H16N2O2
Molecular Weight
340.37
References & Citations
[1]Jun Yang, et al. Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction. Cell Chem Biol. 2023 Mar 16;30 (3) :278-294.e11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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