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GSK3145095

CAT: 0804-HY-111946-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-111946-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
CAS Number
1622849-43-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk3145095.html
Purity
99.39
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC1=CC(F)=CC2=C1NC([C@@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O
Molecular Formula
C20H17F2N5O2
Molecular Weight
397.38
Precautions
H302, H315, H319
References & Citations
[1]Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10 (6) :857-862.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

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BA3501-5.1GSK3145095
A19427-50GSK3145095 50mg
A19427-10GSK3145095 10mg
A19427-100GSK3145095 100mg
A19427-25GSK3145095 25mg
A19427-5GSK3145095 5mg
A19427-1GSK3145095 1mg
A19427-10mM-DGSK3145095 10mM * 1mL in DMSO

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