DIBAC-GGFG-NH2CH2-Dxd

DIBAC-GGFG-NH2CH2-Dxd

• CAS Number: 2758875-01-1
• UNSPSC Description: DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates[1]. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1][2].
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/dibac-ggfg-nh2ch2-dxd.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O
• Molecular Weight: 1128.16
• References & Citations: [1]Amy Han, et al. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use. WO2022015656A1|[2]Protein-drug conjugates comprising camptothecin analogs and methods of use thereof
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported