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Phthalazine

CAT: 0804-HY-W002016-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W002016-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phthalazine is a substrate for human aldehyde oxidase 1, which can lead to the production of ROS and subsequent enzyme inactivation. Phthalazine is a nitrogen-containing organic heterocyclic compound. Phthalazine exhibits antitumor activity in blood cancer, breast cancer, colon cancer, lung cancer and renal cancer[1][2].
CAS Number
253-52-1
UNSPSC
12352005
Hazard Statement
H341, H412
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phthalazine.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C12=CC=CC=C1C=NN=C2
Molecular Formula
C8H6N2
Molecular Weight
130.15
Precautions
H341, H412
References & Citations
[1]Garrido C, et al., The Inactivation of Human Aldehyde Oxidase 1 by Hydrogen Peroxide and Superoxide. Drug Metab Dispos. 2021 Sep;49 (9) :729-735. |[2]Sangshetti, J., et al., (2019) . Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review. Bioorganic & medicinal chemistry, 27 (18), 3979–3997.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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