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HKSOX-1

CAT: 0804-HY-150175Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150175Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2•−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2•−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2•− roles in inflammation, mitochondrial stress, and other physiological processes[1].
CAS Number
1786411-17-3
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hksox-1-1.html
Smiles
O=C(C1=CC=C2C(C(OC23C4=CC(F)=C(C(F)=C4OC5=C(C(OS(=O)(C(F)(F)F)=O)=C(C=C53)F)F)OS(=O)(C(F)(F)F)=O)=O)=C1)O
Molecular Formula
C23H6F10O11S2
Molecular Weight
712.40
References & Citations
[1]Fluorescent Probe HKSOX‑1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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