α-Dendrotoxin

CAT: 0804-HY-P2707Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P2707Size:1 Each
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Description
α-Dendrotoxin (α-DTX) is a small molecule peptide neurotoxin isolated from the venom of the African green mamba snake (Dendroaspis angusticeps) . α-Dendrotoxin is also a KV1.1, KV1.2, KV1.6 and ASIC channel blocker. α-Dendrotoxin blocks potassium channels, lowers the threshold of neuronal action potentials, and increases the frequency of action potentials, thereby enhancing neuronal excitability. α-Dendrotoxin can be used in neurotoxicology research[1].
CAS Number
[74504-53-3]
Product Name Alternative
α-DTX
UNSPSC
12352209
Hazard Statement
H300
Target
Potassium Channel; Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/α-dendrotoxin.html
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H]1C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N3[C@@H](CCC3)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H]4C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N6[C@@H](CCC6)C(N[C@@H](C)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H]%10C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%12=CNC%13=CC=CC=C%12%13)C(N[C@@H](CO)C(NCC(N[C@@H](CSSC4)C(NCC(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%14=CC=CC=C%14)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC%10)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC1)C(N[C@@H]([C@@H](C)CC)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]%15N([C@](N%16)(C=O)CCC%16=O)CCC%15
Molecular Formula
C305H472N98O84S6
Molecular Weight
7048.01
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Bekkers J M, et al. Modulation of excitability by α-dendrotoxin-sensitive potassium channels in neocortical pyramidal neurons[J]. Journal of Neuroscience, 2001, 21 (17) : 6553-6560.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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