Prunin

• Description:

  Prunin is a potent inhibitor of human enterovirus A71 (HEVA71) . Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 μM[1][2].

• Product Name Alternative:

  Naringenin 7-0-glucoside

• UNSPSC:

  12352005

• Hazard Statement:

  H410

• Target:

  Enterovirus; Phosphatase

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/prunin.html

• Purity:

  99.24

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13

• Molecular Formula:

  C21H22O10

• Molecular Weight:

  434.39

• Precautions:

  H410

• References & Citations:

  [1]Gunaseelan S, et al. Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection. Sci Transl Med. 2019 Oct 30;11 (516) . pii: eaar5759.|[2]Jung HA, et al. Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. Arch Pharm Res. 2017 Jan;40 (1) :37-48.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [529-55-5]