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CYH4 rabbit pAb

CAT: 0855-ES17132-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES17132-01Size:50 µL
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Background
This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Description
This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],
UniProt
Q9UIA0
Swiss Prot
Q9UIA0
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human CYH4 AA range: 150-200
Target
CYH4
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein .
Gene ID (Human)
27128

UniProtKB · Q9UIA0

Cytohesin-4

CYH4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UIA0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYTH4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5R3F9, Q9UGT6
Protein keywords

Cellular component

Cell membraneMembrane

Domain

Coiled coil

Molecular function

Guanine-nucleotide releasing factor

Ligand

Lipid-binding

Technical term

Proteomics identificationReference proteome

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