Human E-Cadherin Recombinant Rabbit Monoclonal Antibody [SY0287] - BSA and Azide free (Detector)

Human E-Cadherin Recombinant Rabbit Monoclonal Antibody [SY0287] - BSA and Azide free (Detector)

• Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. In addition to gastric cancer, most female mutation carriers develop lobular carcinoma of the breast.
• Product Name Alternative: Arc 1 antibody CADH1_HUMAN antibody Cadherin 1 antibody cadherin 1 type 1 E-cadherin antibody Cadherin-1 antibody Cadherin1 antibody CAM 120/80 antibody CD 324 antibody CD324 antibody CD324 antigen antibody cdh1 antibody CDHE antibody E-Cad/CTF3 antibody E-cadherin antibody ECAD antibody Epithelial cadherin antibody epithelial calcium dependant adhesion protein antibody LCAM antibody Liver cell adhesion molecule antibody UVO antibody Uvomorulin antibody
• Abbreviation: Cadherin-1 CAM 120/80 Epithelial cadherin E-cadherin Uvomorulin E-Cad/CTF1 E-Cad/CTF2 E-Cad/CTF3 CD324 CDH1 CDHE, UVO
• CAS Number: 9000-83-3
• Swiss Prot: P12830 Human
• Cellular Locus: Cell junction. Cell membrane. Cytoplasm. Endosome. Golgi apparatus. Membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human E-cadherin aa 155-707.
• Isotype: IgG
• Clone: SY0287
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Positive Control: Recombinant Human E-Cadherin protein (HA210886).
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH09-02] to Human E-Cadherin antibody (Capture) (HA723055) and Recombinant Human E-Cadherin protein (HA210886) as the standard. The reference range value is 156-20,000pg/ml.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes