Protosappanin A
CAT:
804-HY-113573-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Protosappanin A
- CAS Number: 102036-28-2
- UNSPSC Description: Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].
- Target Antigen: Interleukin Related; JAK; STAT
- Type: Natural Products
- Related Pathways: Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/Protosappanin_A.html
- Purity: 99.98
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: O=C1CC2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3OC1
- Molecular Weight: 272.25
- References & Citations: [1]Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15(9):674-679.|[2]Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14(4): 558- 569.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported