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Protosappanin A

CAT: 0804-HY-113573-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113573-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].
CAS Number
102036-28-2
Product Name Alternative
PTA
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Interleukin Related; JAK; STAT
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Protosappanin_A.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1CC2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3OC1
Molecular Formula
C15H12O5
Molecular Weight
272.25
Precautions
H315, H319
References & Citations
[1]Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15 (9) :674-679.|[2]Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14 (4) : 558- 569.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
JAK2; STAT3

Alternative Products

CatalogName
MBS3843414-01Protosappanin A
AB1853Protosappanin B
A18956-100Protosappanin A 100mg
A18956-50Protosappanin A 50mg
A18956-10Protosappanin A 10mg
A18956-5Protosappanin A 5mg
A18956-1Protosappanin A 1mg
A18956-25Protosappanin A 25mg

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