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Metoclopramide-d3

CAT: 0804-HY-17382SSize: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-17382SSize:500 µg
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Description
Metoclopramide-d3 is deuterium labeled Metoclopramide. Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis[1][2].
CAS Number
1216522-89-2
UNSPSC
12352005
Hazard Statement
H302
Target
5-HT Receptor; Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
CCN(CC)CCNC(C1=C(C=C(C(Cl)=C1)N)OC([2H])([2H])[2H])=O
Molecular Formula
C14H19D3ClN3O2
Molecular Weight
302.81
Precautions
P264-P270-P330-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bhosale KB, et, al. Dose-dependent response of central dopaminergic systems to metoclopramide in mice. Indian J Exp Biol. 1997 Jun;35 (6) :618-22.|[3]Edwards CR, et, al. In vivo and in vitro studies on the effect of metoclopramide on aldosterone secretion. Clin Endocrinol (Oxf) . 1980 Jul;13 (1) :45-50.|[4]Gomes RCT, et, al. Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle. Clinics (Sao Paulo) . 2011;66 (6) :1101-4.|[5]Hirokawa Y, et, al. Synthesis and structure-activity relationships of 4-amino-5-chloro-N- (1,4-dialkylhexahydro-1,4-diazepin-6-yl) -2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist. Chem Pharm Bull (Tokyo) . 2002 Jul;50 (7) :941-59.|[6]Rao AS, et, al. Review article: metoclopramide and tardive dyskinesia. Aliment Pharmacol Ther. 2010 Jan;31 (1) :11-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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