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TIM-3-IN-2

CAT: 0804-HY-155175-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155175-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM) . TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines[1].
CAS Number
1113126-49-0
UNSPSC
12352005
Target
Tim3
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tim-3-in-2.html
Purity
98.93
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=C(C=C(C=C1)OC)OC)COC2=CC=CC(C3=NC(C4=CC=C(C=C4)OC)=NO3)=C2
Molecular Formula
C25H23N3O6
Molecular Weight
461.47
References & Citations
[1]Abdel-Rahman SA, et al. Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening. J Med Chem. 2023 Aug 24;66 (16) :11464-11475.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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