D-Allose-13C-2

• Description:

  D-Allose-13C-2 is the 13C labeled D-Allose (HY-128741) . D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities[1][2][5].

• UNSPSC:

  12352211

• Target:

  Akt; Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; PI3K; Reactive Oxygen Species (ROS)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; PI3K/Akt/mTOR

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-allose-13c-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C[C@@H]([C@@H]([13C@@H]([C@@H](CO)O)O)O)O

• Molecular Formula:

  C5 13CH12O6

• Molecular Weight:

  181.15

• References & Citations:

  [1]Chen Z, et al., Recent research on the physiological functions, applications, and biotechnological production of D-allose. Appl Microbiol Biotechnol. 2018 May;102 (10) :4269-4278. |[2]Sui L, et al., Growth inhibitory effect of D-allose on human ovarian carcinoma cells in vitro. Anticancer Res. 2005 Jul-Aug;25 (4) :2639-44.|[3]Gao D, et al., Anti-inflammatory effect of D-allose in cerebral ischemia/reperfusion injury in rats. Neurol Med Chir (Tokyo) . 2013;53 (6) :365-74.|[4]Akumwami S, et al., Effects of D-Allose on experimental cardiac hypertrophy. J Pharmacol Sci. 2024 Oct;156 (2) :142-148.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported