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Thianthrene

CAT: 0804-HY-W014120-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W014120-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) . Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC50 = 23 μM) . Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo[1][2].
CAS Number
92-85-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thianthrene.html
Purity
99.99
Solubility
DMSO : 11.11 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=CC=CC=C1SC3=C(C=CC=C3)S2
Molecular Formula
C12H8S2
Molecular Weight
216.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Mitchell SC, et al. Fate of thianthrene in biological systems. Xenobiotica. 2017 Aug;47 (8) :731-740. |[2]Jaspreet Kaur, et al., (2021), Thianthrene is a novel inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) Journal of Molecular Biochemistry
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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