Leptomycin A

• Description:

  Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H225-H301+H311+H331-H370

• Target:

  Antibiotic; CRM1; HIV

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/leptomycin-a.html

• Purity:

  99.0

• Solubility:

  Methanol : 10 mg/mL (ultrasonic;warming)

• Smiles:

  O=C (O) /C=C (C) /C[C@H] (C) [C@@H] (O) [C@H] (C) C ([C@H] (C) /C=C (C) /C=C/C[C@@H] (C) /C=C (C) \C=C\[C@H]1[C@@H] (C) C=CC (O1) =O) =O

• Molecular Formula:

  C32H46O6

• Molecular Weight:

  526.70

• Precautions:

  P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

• References & Citations:

  [1]Kudo, N., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242 (2), 540-547 (1998) .|[2]Wolff B, et al. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol. 1997 Feb;4 (2) :139-47.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  87081-36-5