Leptomycin A

• Target :

  HIV Protease|||CRM1|||Antibiotic

• Related Pathways :

  Proteases/Proteasome|||Microbiology/Virology|||Membrane transporter/Ion channel

• Bioactivity :

  Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins.

• Smiles :

  C[C@H](C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O)\C=C(\C)/C=C/[C@@H]1OC(=O)C=C[C@@H]1C

• Molecular Formula :

  C32H46O6

• Molecular Weight :

  526.7

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  87081-36-5