Leptomycin A

• Target:

  HIV Protease|||CRM1|||Antibiotic

• Related Pathways:

  Proteases/Proteasome|||Microbiology/Virology|||Membrane transporter/Ion channel

• Bioactivity:

  Leptomycin A, a metabolite derived from Streptomyces, acts as an inhibitor of CRM1 (exportin 1) and effectively suppresses HIV-1 replication. Compared to Leptomycin B, it exhibits lesser potency. Leptomycin A hampers the interaction between CRM1 and nuclear export signals, effectively hindering the nuclear export of a wide array of proteins.

• Smiles:

  C[C@H] (C\C=C\C (\C) =C\[C@@H] (C) C (=O) [C@@H] (C) [C@H] (O) [C@@H] (C) C\C (C) =C\C (O) =O) \C=C (\C) /C=C/[C@@H]1OC (=O) C=C[C@@H]1C

• Molecular Formula:

  C32H46O6

• Molecular Weight:

  526.7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  87081-36-5