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SIAH1 rabbit pAb

CAT: 0855-ES13109-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13109-01Size:50 µL
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Background
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Description
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008],
UniProt
Q8IUQ4
Swiss Prot
Q8IUQ4
Reactivity
Human; Rat
Immunogen
Synthesized peptide derived from human SIAH1 AA range: 157-207
Target
SIAH1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.
Gene ID (Human)
6477

UniProtKB · Q8IUQ4

E3 ubiquitin-protein ligase SIAH1

SIAH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IUQ4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIAH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
A0FKF3, O43269, Q49A58, Q92880
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell cycleDifferentiationSpermatogenesisUbl conjugation pathway

Cellular component

CytoplasmNucleus

Molecular function

Developmental proteinTransferase

Disease

Disease variantIntellectual disability

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

Domain

Zinc-finger

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