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MKC-8866

CAT: 0026-B2785-5Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B2785-5Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MKC-8866 is a potent, and selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC-8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50 of 0.14 μM. MKC-8866 also strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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