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Dichlorobenzamil

CAT: 0804-HY-164684Size: 1 EachDry Ice: NoHazardous: No
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Description
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits 45Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC50 = 18 μM) . Dichlorobenzamil can also block K+ channels and voltage-sensitive Ca2+ channels[1].
CAS Number
1166-01-4
Product Name Alternative
3',4'-Dichlorobenzamil; L-594881
UNSPSC
12352005
Target
Calcium Channel; Na+/Ca2+ Exchanger; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dichlorobenzamil.html
Smiles
O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=C(C(Cl)=C2)Cl)=N
Molecular Formula
C13H12Cl3N7O
Molecular Weight
388.64
References & Citations
[1]Plasman P O, et al. Inhibition of Na/Ca exchange in pancreatic islet cells by 3′, 4′-dichlorobenzamil[J]. Biochemical pharmacology, 1991, 41 (11) : 1759-1768.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3',4'-Dichlorobenzamil

3,5-diamino-N-[amino-[(3,4-dichlorophenyl)methylimino]methyl]-6-chloro-2-pyrazinecarboxamide is a member of guanidines and a member of pyrazines.

CAS Number1166-01-4
PubChem CID114771
IUPAC Name3,5-diamino-6-chloro-N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]pyrazine-2-carboxamide
Molecular FormulaC13H12Cl3N7O
Molecular Weight388.6
XLogP3
Topological Polar Surface Area145
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity480
SMILES
C1=CC(=C(C=C1CN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)Cl)Cl
InChI
InChI=1S/C13H12Cl3N7O/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24)
InChIKey
OSHKWEFWXCCNJR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3',4'-Dichlorobenzamil
CAS: 1166-01-4
CID: 114771
Formula: C13H12Cl3N7O
MW: 388.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.6
XLogP33
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass387.016891
Monoisotopic Mass387.016891
Topological Polar Surface Area145 Ų
Heavy Atom Count24
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
HY-W777037-012,3-Dichlorobenzamidyl Guanidine-13C2
HY-W142446S-012,6-Dichlorobenzamide-3,4,5-d3

Alternative Products

CatalogName
MBS565603-012',4'-Dichlorobenzamil. HCl
DMB62115-013′,4′-Dichlorobenzamil hydrochloride
MBS57761183',4'-Dichlorobenzamil HCl
sc-2001972',4'-Dichlorobenzamil • HCl

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