MOZ-IN-3

• UNSPSC Description:

  MOZ-IN-3 (Compound 6j) is a KAT6A (MOZ) acetyltransferase inhibitor (IC50: 30 nM). MOZ-IN-3 has antitumor activity against four different myeloid leukemia cell lines (HL-60, U937, SKNO-1, K562). MOZ-IN-3 has favorable metabolic stability and pharmacokinetics[1].

• Target Antigen:

  Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/moz-in-3-1.html

• Solubility:

  DMSO : ≥ 200 mg/mL

• Smiles:

  FC1=C(C(CNS(=O)(C2=CC=CC3=C2N=CC=C3)=O)=O)C=CC=C1

• Molecular Weight:

  344.36

• References & Citations:

  [1]Duan Y, et al. Discovery of N-(2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy. Eur J Med Chem. 2023 Aug 26;260:115770.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported