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Serum Response Factor Antibody / SRF

CAT: 0800-V9737-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V9737-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF-binding sites are also constitutive promotor elements in many muscle-specific promotors. At the c-Fos SRE, formation of a ternary complex containing SRF and its accessory protein p62TCF appears to be important for signal transduction. Two related Ets domain proteins, Elk-1 and SRF accessory protein-1 (SAP-1), have DNA binding properties identical to that of p62TCF. Elk-1 and SAP-1 contain two homologous regions of which the two amino-terminal regions, the Ets domain (box A) and the B box, mediate ternary complex formation with SRF. The third homologous region, the C box located toward the C-terminus of the proteins, contains conserved consensus phosphorylation sites for MAP kinases.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Flow cytometry: 1-2ug/million cells, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P11831
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the Serum Response Factor antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
PCRP-SRF-1F7
Applications
ELISA, IF, WB, FACS, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Serum Response Factor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Serum Response Factor antibody is available for research use only.
Storage Conditions
Aliquot the Serum Response Factor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Serum Response Factor antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human colon tissue with Serum Response Factor antibody (clone PCRP-SF7-1F1) at 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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