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IL1 beta Antibody / IL1B

CAT: 0800-V9632-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9632-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating)
UniProt
P01584
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human IL1B protein was used as the immunogen for the IL1B antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
IL1B/465
Applications
ELISA
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the IL1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IL1B antibody is available for research use only.
Storage Conditions
Aliquot the IL1B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the IL1B antibody should be determined by the researcher.
Location
Cytoplasm, Extracellular (secreted)
Image Legend
SDS-PAGE analysis of purified, BSA-free IL1B antibody (clone IL1B/465) as confirmation of integrity and purity.

UniProtKB · P01584

Interleukin-1 beta

IL1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01584
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-1 beta
EC number
—
Processing
Precursor
Secondary accessions
Q53X59, Q53XX2, Q7M4S7, Q7RU01, Q96HE5, Q9UCT6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

CytokineMitogenPyrogen

Cellular component

CytoplasmLysosomeSecreted

Biological process

Inflammatory response

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