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IL1 beta Antibody / IL1B

CAT: 0013-GTR18571150-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571150-01Size:20 µg
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Description
This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
UniProt
P01584
Reactivity
Human
Immunogen
Recombinant full-length human IL1B protein was used as the immunogen for the IL1B antibody.
Clonality
Monoclonal
Clone
IL1B/465
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein A/G affinity
Dilution
ELISA (order BSA-free format for coating)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the IL1B antibody should be determined by the researcher.
Tested Applications
ELISA
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · P01584

Interleukin-1 beta

IL1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01584
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-1 beta
EC number
—
Processing
Precursor
Secondary accessions
Q53X59, Q53XX2, Q7M4S7, Q7RU01, Q96HE5, Q9UCT6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

CytokineMitogenPyrogen

Cellular component

CytoplasmLysosomeSecreted

Biological process

Inflammatory response

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