DMRT2 Antibody

CAT: 0800-V9601SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V9601SAF-100UGSize:100 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene (s) on chr 9. Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity) .
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Western blot: 1-2 µg/mL
UniProt
Q9Y5R5
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human DMRT2 protein was used as the immunogen for the DMRT2 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
PCRP-DMRT2-1B11
Applications
FACS, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the DMRT2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DMRT2 antibody is available for research use only.
Storage Conditions
Aliquot the DMRT2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the DMRT2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using DMRT2 antibody (clone PCRP-DMRT2-1B11) . These results demonstrate the foremost specificity of the PCRP-DMRT2-1B11 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
Product Datasheet
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