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IL1 beta Antibody / IL1B

CAT: 0800-V9593-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9593-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The IL1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P01584
Host
Mouse
Reactivity
Human
Immunogen
A recombinant protein fragment was used as the immunogen for the IL1B antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
IL1B/3993
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the IL1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IL1B antibody is available for research use only.
Storage Conditions
Aliquot the IL1B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the IL1B antibody should be determined by the researcher.
Location
Cytoplasm, Extracellular (secreted)
Image Legend
IHC staining of FFPE human adrenal gland with IL1B antibody (clone IL1B/3993) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P01584

Interleukin-1 beta

IL1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01584
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-1 beta
EC number
—
Processing
Precursor
Secondary accessions
Q53X59, Q53XX2, Q7M4S7, Q7RU01, Q96HE5, Q9UCT6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

CytokineMitogenPyrogen

Cellular component

CytoplasmLysosomeSecreted

Biological process

Inflammatory response

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